HANSOH PHARMA EXPANDED THEIR PARTNERSHIP WITH BIOTHEUS FOR DEVELOPING EGFR/CMET BISPECIFIC ANTIBODY-DRUG CONJUGATES
On March 14, 2024, Hansoh Pharmaceutical Group Co., Ltd. (Hansoh Pharma, 03692.HK), China's leading innovation-driven pharmaceutical company, and Biotheus Inc. (Biotheus), a clinical-stage biotech company focusing on the discovery and development of biologics for oncology and inflammatory diseases, jointly announced that the two parties will further expand their strategic collaboration, following their current partnership since 2022. Biotheus will grant Hansoh Pharma a license to use the
proprietary anti-EGFR/cMet bispecific antibody HS-20117/PM1080 independently developed by Biotheus for the development of antibody-drug conjugates products ("ADC Product").
Under the terms of the agreement, Hansoh Pharma will obtain exclusive worldwide rights from Biotheus to use HS-20117/PM1080 for the development, production, and commercialization of ADC Product, with the right of sublicense. Biotheus will be eligible to receive up to 5 billion RMB in upfront and success-based milestones for ADC Product, as well as tiered royalties based on global net sales from Hansoh Pharma.
HS-20117/ PM1080 is a 1+1 heterodimeric structure of EGFR/cMet bispecific antibody, which can inhibit the growth and survival of tumors by specifically targeting the tumor antigens EGFR and cMet, and is currently in phase I clinical trials.
“We are delighted to expand our partnership with Biotheus.” Said Ms Eliza Sun, Executive Director of the Board at Hansoh. “This collaboration combines Hansoh’s proprietary ADC Platform technology with Biotheus’ novel bispecific antibody. We hope this new approach will further increase the clinical benefit in patients with NSCLC or other solid tumors. We are confident in our ability to offer transformative treatment options to cancer patients in China and worldwide. This is made possible through our extensive experience in clinical development, exceptional commercialization efforts, and external partnerships.”
“This is the second collaboration between Hansoh and Biotheus. We really appreciate Hansoh’s confidence in the potential of PM1080”, said Mr. Xiaolin Liu, Co-founder, Chairman and Chief Executive Officer of Biotheus. “Bispecific ADCs have a potential advantage for better tumor enrichment, overall efficacy and safety. Hansoh develops an outstanding ADC platform, and this collaboration will facilitate the synergy between Hansoh’s ADC expertise and Biotheus’ antibody capabilities. Through this collaboration, we hope to develop a novel EGFR/MET bispecific ADC with better efficacy and safety for cancer patients worldwide.”
About Biotheus Inc.
Biotheus is a clinical-stage biotech company dedicated to the discovery, development, and delivery of novel antibodies to address the unmet medical needs of patients with oncology and inflammatory diseases worldwide. Since its inception, Biotheus has established several innovative platforms for antibody discovery. With an experienced R&D team, Biotheus has built a differentiated product pipeline with programs at various stages.
Hansoh Pharma is a leading innovation-driven pharmaceutical enterprise headquartered in China. With the mission of "continuous innovation for better life", the company focuses on major disease therapeutic areas such as oncology, anti-infectives, central nervous system (CNS), metabolism and immunology. Hansoh Pharma has launched 7 innovative drugs that generate product sales in China, with the revenue from innovative drugs and collaborative products exceeding 80%, forming a rich product pipeline. The company has consistently ranked among the top 100 global pharmaceutical companies and is recognized as one of the top 3 pharmaceutical R&D enterprises in China and is designated as a National Key High-Tech Enterprise and a National Technology Innovation Demonstration Enterprise. Hansoh Pharma was listed on the Hong Kong Stock Exchange in June 2019 (stock code: 03692.HK).
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