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2024 AACR | HANSOH PHARMA PRESENTS CLINICAL DATA ON HS-10370 PHASE I STUDY AT AACR ANNUAL MEETING
Release Date:2024/04/12
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The 115th Annual Meeting of the American Association for Cancer Research (AACR) was convened in San Diego from April 5 to 10. At this year's meeting, Hansoh Pharma released the results of the Phase I Study of HS-10370 monotherapy in a poster presentation. The study drug was a potent highly-selective small molecular KRAS G12C inhibitor (research and development code: HS-10370) administered orally, that was independently developed by Hansoh Pharma for the treatment of advanced solid tumors.

 


The results of the Phase I dose-escalation study show that HS-10370 demonstrates a favorable safety and tolerability profile in patients with advanced solid tumors; and the investigational drug also proves to have good efficacy in the treatment of advanced solid tumors (especially NSCLC) with KRAS G12C mutations. It is expected to become a new treatment option for cancer patients.

 

KRAS mutations cause proteins to grow uncontrollably and continuously activate downstream signaling pathways, thereby leading to cancer growth. Globally, KRAS G12C is known as the most common KRAS mutation subtype in lung cancer. However, no drug for this has yet been approved in China, and there is a significant unmet clinical need in this therapeutic area.

 

Hansoh Pharma will continue to explore the therapeutic potential of HS-10370 monotherapy and combination therapy in multiple tumor types, and expedite the approval and implementation of relevant clinical trials with the hope of providing patients with better regimes soon.


About Hansoh Pharma

Hansoh Pharma is a leading innovation-driven pharmaceutical enterprise headquartered in China. With the mission of "continuous innovation for better life", the company focuses on major disease therapeutic areas such as oncology, anti-infectives, central nervous system (CNS), metabolism and immunology. Hansoh Pharma has launched 7 innovative drugs that generate product sales in China, with the revenue from innovative drugs and collaborative products exceeding 80%, forming a rich product pipeline. The company has consistently ranked among the top 100 global pharmaceutical companies and is recognized as one of the top 3 pharmaceutical R&D enterprises in China and is designated as a National Key High-Tech Enterprise and a National Technology Innovation Demonstration Enterprise. Hansoh Pharma was listed on the Hong Kong Stock Exchange in June 2019 (stock code: 03692.HK).

Statements

1. This announcement is intended for healthcare professionals only and not for advertising purposes.2. Hansoh Pharma does not recommend the use of any unapproved drugs or off-label indications, nor does it make recommendations regarding any drug or indication.3. The information provided in this announcement is for reference only; please follow the advice or guidance of a physician or other healthcare professional. Any treatment-related decisions made by healthcare professionals should be based on the specific circumstances of the patient and should be used in accordance with the instructions for the drug.4. For more detailed information about any company products, medical treatments, or diseases, please consult a healthcare professional.

Forward-Looking Statements

This press release is intended to provide information about Hansoh Pharmaceutical Group Co., Ltd. and its affiliates, including their subsidiaries (collectively referred to as "Hansoh Pharma"). It does not constitute a disclosure of information about Hansoh Pharma or any investment recommendations.The information contained in this release may include forward-looking statements related to Hansoh Pharma's business and product prospects, as well as its plans, beliefs, expectations, and strategies. These statements are predictions based on speculative assumptions and are not guarantees of future performance. They are subject to risks and uncertainties, such as scientific, commercial, political, economic, financial, legal factors as well as competitive environment and social conditions, many of which are beyond Hansoh Pharma's control and difficult to predict, thus actual results may differ significantly from what is stated here, and past securities price trends should not be used as a guide for future market conditions. As such, investors should exercise caution when using this information to make investment decisions. Phrases such as "commit," "expect," "believe," "predict," "anticipate," "forecast," "intent,"“project,” “may,” “will,” “should,” “plan,” “could,” “continue,” “target,” “contemplate,” “estimate,” “guidance,” “possible,” “potential,” “pursue,”“likely,”and words and terms of similar terms substance used in connection with any discussion of future plans, actions or events indicate forward-looking statements.Hansoh Pharma does not commit to or guarantee the accuracy, timeliness, or completeness of forward-looking information and assumes no obligation to update or revise these forward-looking statements. Neither Hansoh Pharma nor any of its directors, employees, or agents will be responsible for any forward-looking statements that prove to be inaccurate or unachievable and any losses or damages incurred by users due to reliance on the information provided herein, including but not limited to direct, incidental, indirect, or punitive damages.All information in this press release is current as of the date of release. Hansoh Pharma assumes no responsibility to update or revise this information in light of new developments, future events, or other circumstances, except as required by law. Additionally, Hansoh Pharma reserves the right to make changes, corrections, or discontinuations to all or part of the content of this press release at any time without notice. For information specifically related to the listed company, investors are encouraged to refer to the announcements and financial reports of Hansoh Pharma (03692.HK).